Cell proliferation depends on mitochondrial Ca2+uptake: inhibition by salicylate
نویسندگان
چکیده
منابع مشابه
Bartonella-associated endothelial proliferation depends on inhibition of apoptosis.
Bartonella is a Gram-negative pathogen that is unique among bacteria in being able to induce angioproliferative lesions. Cultured human endothelial cells have provided an in vitro system in which to study the basis of angioproliferation. Previous studies have attributed the organism's ability to induce angioproliferative lesions to direct mitotic stimulation of endothelial cells by these bacter...
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Background—Salicylates may have direct vascular effects by mechanisms that are independent of platelet inhibition. Methods and Results—We investigated the effect of salicylates on vascular smooth muscle cell (SMC) proliferation in response to platelet-derived growth factor (PDGF) in vitro. Salicylate concentrations of 5 and 10 mmol/L inhibited serumor PDGF-induced SMC cell count and [H]thymidin...
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The rise in DNA synthesis in regenerating rat liver is inhibited by azathioprine (40 mg/kg). Regeneration in the presence of azathioprine occurs by hypertrophy as assessed both by an increase in the ratio of RNA or protein to DNA and by an increase in diameter of the hepatocytes. Mitoses that occur in azathioprine-treated regenerating liver result from a G2 population that is apparently stimula...
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In order to verify the hypothesis that intestinal cell proliferation is controlled by a mitotic inhibitor, extracts of villous epithelial cells from different species were analysed to study their effect on the proliferation of various intestinal cells. Villous extracts from rat and rabbit strongly and reversibly inhibited cell division and DNA synthesis in a rat intestinal epithelial cell line ...
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Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2006
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2005.100586